منابع مشابه
Welcome to Silence
Editorial Welcome to Silence [1], a new open-access journal devoted to RNA silencing and other pathways directed by non-coding RNAs. Silence springs from the extraordinary, yet brief, history of RNA silencing. In just two decades, we have seen the anomalous properties of plant and fungal transgenes connect with a series of amazing experiments in which injected double-stranded RNA triggered sile...
متن کاملDAMD to epigenetic silence.
F or many decades, cancer research focused on genetic changes that led to tumorigenesis. However, it is now established that epigenetics also plays an important role in cancer initiation and development (1, 2). The cancer epigenome is marked by a global decrease in methylation, leading to genomic instability and increased methylation at promoters, which in turn leads to gene silencing (3). The ...
متن کاملPol V Transcribes to Silence
In most cases, the functions of long noncoding RNAs remain uncertain. Working in the model plant Arabidopsis, Wierzbicki et al. (2008) provide evidence that transcription of intergenic noncoding regions by RNA polymerase V promotes heterochromatin formation and silencing of nearby genes.
متن کاملNetwork externalities, complementarities, and invitations to enter
We discuss the incentive of an exclusive holder of a technology to share it with competitors in a market with network externalities. We assume that high expected sales increase the willingness to pay for the good. This is named the 'network effect'. At a stable fulfilled expectations equilibrium, where the actual sales are equal to the expected ones, it is shown that. if the network effect is s...
متن کاملEnter Sofosbuvir: The Path to Curing HCV
The decision to leave the security of a large pharmaceutical company and jump into the unknown of a small biotech called Pharmasset with 15 staff members, limited capabilities, no labs, and little money would to many seem a foolish decision. In fact, many advised me to not make the move. But the desire and excitement to blaze a new trail where none had been, to build a research team where one b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2006
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2007